HERVs & Disease First International Workshop on Human Endogenous Retroviruses and Diseases

HERVs & Disease
First International Workshop on Human Endogenous
Retroviruses and Diseases

Organizing committee

Hervé Perron – GeNeuro Innovation, Lyon-France
Patrice Marche – INSERM and Joseph Fourier University, Grenoble-France
François Curtin – GeNeuro, Geneva-Switzerland
Jean-Louis Touraine – University of Lyon-France

Tuesday 26th may 2015

8h00-8h30 : Welcome of the participants and coffee

Opening of the Session and Introduction
Chairpersons : Hervé Perron & Jean-Louis Touraine

Introductory Presentation
8h45-9h30     Cedric Feschotte – Department of Human Genetics, University of Utah, USA
Of Good and Evil : Biological Impact of Endogenous Retroviruses and Other Invasive Genetic Elements

Neurological Diseases and HERVs

Chairpersons : Avindra Nath & Guilherme Sciascia do Olival

9h30-10h00     Avindra Nath- NIH, NINDS, Bethesda, USA
Amyotrophic Lateral Sclerosis and HERV-K

10h00-10h30     Alain Créange- University Hospital Henri Mondor, Créteil, France
Chronic Inflammatory Demyelinating Polyneuropathies and HERV-W

10h30-10h45 Coffee Break

10h45-11h15     Mario Clerici- University of Milan, Italy
Neuroinflammation in Alzheimer’s and Parkinson’s diseases. Should HERVs be studied in this context?

11h15-11h45     Hervé Perron- Geneuro-Innovation, Lyon, France
Multiple Sclerosis and HERVs

12h00-13h30 Lunch Break

13h30-14h00     Patrick Küry- University of Düsseldorf, Germany
Remyelination impairment and HERV-W in Multiple Sclerosis

14h00-14h30     Jack van Horssen- VU-University, Amsterdam, The Netherlands
HERV-W Env and Gag immunohistology in cohorts of MS and control brains

14h30-15h00     John Kriesel – University of Utah, USA
HERV RNA in MS brain

15h00-15h30     Ranjan Dutta & David Kremer – Cleveland Clinic, Ohio, USA
HERVs in Progressive Multiple Sclerosis

15h30-16h00     Antonina Dolei- University of Sassari, Italy
Interplay between EBV and HERV-W in Multiple Sclerosis

16h00-16h15 Coffee Break

16h15-16h45     Camila Romano or Guilherme Sciascia do Olival – University of Sao Paulo, Brazil
HERV-W/MRSV envelope transcripts detection in blood of multiple sclerosis patients after Natalizumab treatment

16h45-17h15     Alexander Emmer & Malte Kornhuber – Martin-Luther-University Halle-Wittenberg, Germany
HERV superantigen mediated encephalitis

17h15-17h45     Raphaël Faucard & Alexandra Madeira – GeNeuro Innovation, France, University of Bern
Pharmacokinetics of HERV-W Env interaction with Toll-like receptor 4 and its inhibition by neutralizing antibodies

17h45-18h15     François Curtin & Alois Lang- GeNeuro, Geneva, Switzerland; University of Bern
GNbAC1, a humanized IgG4 antibody neutralizing HERV-W Envelope protein; pre-clinical development and Results from Phase I/IIa clinical trials in Healthy volunteers and in MS patients

18h15-18h45     General discussion

18h45-19h00     Conclusions and end of the session

Wednesday 27th may 2015

8h00-8h30 : Welcome of the participants and coffee

Introductory Presentation

Chairpersons : Hervé Perron & to be confirmed

8h45-9h30     F. Arnaud, B. Viginier, A. Armezzani, C. Terzian and M. Palmarini – University of Lyon, France
and MRC-Center for Virus Research, Glasgow-UK
“Friendly viruses”: antiviral activities of ERVs against the oncogenic Jaagsiekte sheep retrovirus,
the etiologic agent responsible for ovine pulmonary adenocarcinoma in sheep

Neuropsychiatric Diseases and HERVs

Chairpersons : to be confirmed
9h30-10h00     Hakan Karlsson – Karolinska Institute, Sweden
Title expected

10h00-10h30     Marion Leboyer & Ryad Tamouza – FondaMental, INSERM & University of Créteil, France
Inflammatory psychoses and HERV-W

10h30-10h45 Coffee Break

10h45-11h15     Hervé Perron – Geneuro-Innovation, Lyon, France
HERV-W env Transgenic mouse model for neurobehavioral pre-clinical studies in Schizophrenia

11h05-11h35     Laurent Groc – University of Bordeaux, France
Molecular imaging and specific neuronoglial reactivity to HERV-W Envelope

11h35-11h55     Edouard Kouassi – University of Montreal, Quebec, Canada
The Canadian «signature bank» of biological materials, clinical and psychosocial data as a tool for the study
of the role of HERV-W in mental disorders

12h00-13h30 Lunch Break

Diabetes, other diseases and HERVs

Chairpersons : to be confirmed
13h30-14h00     Marion Schneider – University of Ulm, Germany
HERV-W expression in immature dendritic cells from type 2 diabetes

14h00-14h30     Julie Medina – GeNeuroInnovation, Lyon, France
HERV-W expression in pancreas biopsies from Type 1 diabetes and controls

14h30-15h00     Jacques Portoukalian – University of Lyon, France
Effects of HERV-W envelope protein on glucose-induced insulin release of insulinoma cells in vitro and
induction of Type1 diabetes-like model in humanized NOD-SCID mice

15h00-15h30     János András Mótyán – University of Debrecen, Hungary
HERV-W protease activity and gag-encoded proteins

15h30-15h45     Reiner Strick – University Clinic Erlangen, Germany
Dysregulation of ERV genes in human pituitary adenoma and glioblastoma multiforme : Possible
functional role in giant-cell glioblastoma

15h45-16h00 Coffee Break

16h00-16h30     François Mallet – BioMérieux, Hospices Civils de Lyon, France
From sketches of the HERV transcriptome landscape to the clinical evidence of HERV-H specific retroviruses expression  in colorectal carcinoma

16h30-17h00     Martin Staege – Martin-Luther-University Halle-Wittenberg, Germany
HERVs and Hodgkins-lymphoma

17h00-17h45     General Discussion

17h45-18h00     Conclusions and End of the meeting